SURG-21. DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF TUMOR TISSUE FROM NORMAL BRAIN DURING MICROSURGERY BY TISSUE STIFFNESS

Abstract Neurosurgeons perform tumor resection based on their tactile perception. However, many years of experience and training are required to appropriately differentiate tissue from surrounding parenchymal tissue. It was reported that the stiffness human cancer strongly correlates with pathological it can be used as a biomarker. Comprehensive analysis also revealed molecular expression differs greatly between hard soft tumors.Haptics technology measures uses stimulus causes sensation physical quantity. Force is caused by mechanical contact an object. Real Haptics our main research field, which general term for technologies quantify utilize force-tactile stimuli generated objects exist in real world / or virtual world.We have developed microsurgical forceps equipped haptics brain during dissection. We three glioblastoma cell lines (SF126, U87, U251) expressing proteins firefly luciferase mCherry. Each line transplanted into forebrain 5 nude mice. Tumor progression regularly monitored In Vivo Imaging System (IVIS) mice were euthanized at appropriate stage. normal measured using Master-slave integrated haptic device. Importantly, all glioblastomas shown harder than (p=0.047). The median each follows. Normal (n=15): 149.98 N/m, SF126 (n=5): 207.70 U87 214.40 U251 188.86 N/mThis pilot study showed tumors could differentiated brain, might help neurosurgeons dissect margin along plane.